Sunifiram – What it is
Sunifiram, also known as DM-235, is one of the most exciting new developments in nootropics, providing a very powerful cognitive boost along with mood and energy enhancement. First synthesized in 2000, Sunifiram is a very recent discovery and only a limited body of research is available to date, but preliminary animal studies indicate that it’s an effective nootropic proven to improve learning and memory.
There have not been many studies performed, and none with humans. That having been said, there is much anecdotal evidence for the benefits and effects of Sunifiram. It is one of the newest products to join the family of smart drugs. It is considered to be in the ampakine family of supplements. Preliminary animal studies indicate that it’s an extremely effective nootropic proven to improve learning and memory. It is believed to have great potential as a possible treatment for a variety of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and amnesia. Several studies follow:
1. It’s another AMPA receptor modulating smart drug – an Ampakine – Ampakines are so effective at increasing our awareness of the world around us that DARPA has investigated them for military applications. a French study stated: “These results suggest that DM 232 and DM 235 [Sunifiram] act as cognition enhancers through the activation of the AMPA-mediated neurotransmission system.”
2. Additionally, it is a Kinase activator, according to a 2013 Japanese study “Novel nootropic drug Sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.” it’s source of long-term potentiation and improved cognition.
3. It’s also Cholinergic, animal tests show it releases acetylcholine in the cerebral cortex.
Sunifiram – How it Works
Sunifiram works in a similar fashion to other racetams, stimulating many of the same receptors. It is known to stimulate AMPA receptors, which places it in the ampakine family. AMPA activity is directly related to the amount of glutamate within the brain. Glutamate is essential for making new connections between synapses. When your levels of glutamate are low, your cognitive abilities suffer. This results in poor attention span, a poor ability to learn, and issues with memory. By increasing glutamate levels in the brain, Sunifiram increases these cognitive abilities. Acetylcholine levels are also increased. When more acetylcholine is released, users experience higher levels of perception, memory, learning, and focus. There is also increased communication between the two hemispheres of the brain.
Sunifiram – What it “Does”
Unlike Caffeine, Adderall or Piracetam, which will give a productive energy boost, Sunifiram is just going to give your memory and learning capacity an edge. It increases one’s attention span, decision making, and learning abilities. The most dramatic effects are seen with short-term memory recall. Sunifiram increases energy levels by increasing glutamate activity, not by “stimulating” the brain. Because of its effects on memory, it’s currently undergoing investigations as a treatment for those who suffer from Alzheimer’s or other age-related cognitive decline diseases. Sunifiram enhances long-term potentiation. This is the forming of new memory-storage connections.
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